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In a 6 month study of 263 patients with persistent active rheumatoid arthritis despite methotrexate therapy, and with normal lfts, arava was administered to a group of 130 patients starting at 10 mg per day and increased to 20 mg as needed.

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pulmonary function tests may be useful if methotrexate-induced lung disease is suspected, especially if baseline measurements are available see organ system toxicity .

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high dose iv methotrexate made my son very, very sick – despite anti-emetics.

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furosemide may reduce renal clearance of methotrexate.

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methotrexate has the potential for acute elevated transaminases and chronic fibrosis and cirrhosis hepatotoxicity.

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