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In the past, when high doses of digoxin were used and little attention was paid to clinical status or concurrent medications, adverse reactions to digoxin were more frequent and severe.

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however, available evidence suggests that the incidence and severity of digoxin toxicity has decreased substantially in recent years.

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acarbose may interfere with digoxin lanoxin absorption thereby decreasing digoxin blood levels and its effect.

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chan and colleagues suggested that the interaction of digoxin and dialysis on ion fluxes, particularly potassium, could provide a mechanism for digoxin toxicity in this population.

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in a recent california study of kaiser patients, starting digoxin treatment in patients with newly diagnosed atrial fibrillation was linked with a doubled risk of death during the subsequent 8 months.

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